Volume 16 Part 1 Article 87
Title: Use of Ganoderma tsugae for the Treatment of Human Chronic Skin Ulcers
Authors: C.H. Su, B.W. Lin, S.Y. Yu and S.W. Liu
Waste of Ganoderma tsugae fruiting bodies from a health food factory was treated with 1 N KOH and 1% sodium hypochloride to produce a pulp-like white paste. The paste was filtered and lyophilized to produce sacchachitin, a chitin-containing polysaccharide membrane. A clinical study was carried out on patients suffering from chronic skin ulcers (>10 cm) for at least 6 months. Sacchachitin was applied to one-half of the wound area, while the other half remained uncovered as a control. Among 47 patients, 13 were subjected to matrix metallo-proteinases (MMPs) analysis. Fluids were collected from the sacchachitin-treated and control tissues, and subjected to enzyme-linked immunosorbent assay. Denaturing-gel electrophoretic analysis also was performed to examine the binding of MMPs by sacchachitin. Approximately 85% of the patients showed accelerated healing in the sacchachitin treatment. The increased binding of MMPs by sacchachitin was proposed as the mechanism of action.Please login to download the PDF for this proceeding.