Volume 16 Part 1 Article 85
Title: The Anti-androgenic Effect of Ganoderma lucidum
Authors: J. Liu, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, C. Ueda, H. Tajiri, S. Kaneko, Y. Suimi and R. Kondo
Testosterone and its highly active metabolite dihydrotestosterone (DHT) play a role in the development and progression of benign prostatic hyperplasia (BPH) and prostate cancer (CaP). 5α-reductase, which catalyzes the conversion of testosterone to DHT, has been a target of manipulation in the treatment of BPH and CaP. Because of the potential for adverse side effects in using synthetic 5α-reductase inhibitors, current research focuses on developing 5α-reductase inhibitors from natural sources. In East Asia, the fruiting body of Ganoderma lucidum has been used for centuries in medicine. We conducted a study using liver microsomes of the Sprague-Dawley (SD) rat and SD rat BPH model to determine if extracts of G. lucidum exerted 5α-reductase inhibitory and BPH suppressi ve activities. Nineteen species of mushrooms were extracted with methanol and 5α-reductase inhibitory activity of the extract was assayed at a concentration of 200 ppm. Among the fungi tested, extracts of G. lucidum showed the highest activity, significantly inhibiting the growth of the ventral prostate induced by testosterone in castrated rats.Please login to download the PDF for this proceeding.