Volume 17 Part 1 Article 81: Oral Administration of Agaricus brasiliensis S. Wasser et al. suppressed Th2 Response in Mice Sensititzed with Ovalbumin

Volume 17 Part 1 Article 81
Year 2008
Title: Oral Administration of Agaricus brasiliensis S. Wasser et al. suppressed Th2 Response in Mice Sensititzed with Ovalbumin
Author: M. Mizuno

Abstract:

Allergy is a common health problem in developed countries. The incidence of typeⅠallergic disorders has been increasing worldwide, particularly, hypersensitivity to food and airborne allergens. The mechanism of TypeⅠallergy includes a series of events, namely, production of antigen-specific immunoglobulin E (IgE). IgE synthesis is considered to be caused by development and activation of T helper-2 (Th2) cells and B cells. This specific Th2 cell produces predominantly interleukin (IL)-4. In contrast, the T helper 1 (Th1) cells mainly secrete cytokines such as IL-2 and interferon (IFN)-gamma that inhibit IgE and IgG1 secretion and enhance IgG2a secretion. Thus, it seems that shifting the balance from Th2 to Th1 dominance should be a rational strategy to prevent IgE-mediated allergic diseases. In this study, we examined the effect of Agaricus brasiliensis S. Wasser et al. (ABSW) on the balance of Th1/Th2.

Please login to download the PDF for this proceeding.