Volume 17 Part 1 Article 51: Mushroom Polysaccharide Extracts Delay Progression of Carcinogenesis in Mice

Volume 17 Part 1 Article 51
Year 2008
Title: Mushroom Polysaccharide Extracts Delay Progression of Carcinogenesis in Mice
Authors: C.G.O. Wasonga1, S.A. Okoth, J.C. Mukuria and C.O.A. Omwandho

Abstract:

Hepatocellular carcinoma results when cancerous cells are localised in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and, in many cases, inaccurate, due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body’s immune system, increasing a patient’s risk to infection. These observations underscore the need for improved, or additional, methods of cancer diagnosis and management. We investigated the effect of polysaccharide-rich Pleurotus pulmonarius fruit-body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis, suggesting that these extracts may be useful as adjuvants to conventional cancer therapies.

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