Volume 10 Part 2 Article 70: Effect of Shii-take Mushroom on Plasma Cholesterol Levels in Rats

Volume 10 Part 2 Article 70
Year 1979
Title: Effect of Shii-take Mushroom on Plasma Cholesterol Levels in Rats
Authors: S. Tokuda and T. Kaneda

Abstract:

In previous papers, (Tokuda et al., 1974), we reported the reducing mechanism of plasma cholesterol by Shii-take, Lentinus edodes, or Eritadenine, hypocholesterolemic substance in this fungus.

It has been known that plasma cholesterol will be reduced by the following mechanism.
(1) Inhibition of endogenous synthesis of cholesterol.
(2) Promotion of catabolism from cholesterol to bile acids.
(3) Inhibition of reabsorption of cholesterol.
(4) Stimulation of cholesterol excretion.

In order to find the plasma cholesterol reducing mechanism by Shii-take, the effect of th is fungus on the endogenous synthesis of cholesterol was investigated.For this experiment, sodium acetate-1-14C in saline was injected intraperitoneally to rats and radioactivity of synthesized cholesterol was determined. It was noticed that there was no significant difference in plasma cholesterol levels among the groups fed Shii-ta-ke and control. These results indicate that cholesterol synthesis in rats is not affected by Shii-take.

In the next experiment, the amounts of sterols and bile acids which were excreted into feces were determined. As a result, it was observed that the excretion of sterols in rats fed Shii-take increased about 65% compared to that of the control group, while the fecal bile acids did not differ causing in the two groups. This result suggests that one of the effects of Shii-take for reducing plasma cholesterol is the acceleration of cholesterol excretion into feces.

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