Volume 19 Part 1 Article 57: The Medicinal Properties and Efficacy of Cultivated Tiger Milk Mushroom (Lignosus rhinocerotis TM02)

Volume 19 Part 1 Article 57
Year 2016
Title: The Medicinal Properties and Efficacy of Cultivated Tiger Milk Mushroom (Lignosus rhinocerotis TM02)
Author: Tan C.S., Fung S.Y., Tan N.H., Ting K.N., Lee M.K., Renee Lim L.H., and Ng S.T.

Lignosus rhinocerotis, commonly known as Tiger Milk Mushroom, has been used for more than 400 years by South East Asian communities for its healing properties on more than 15 types of medical ailments including asthma, fever, cough, cold, sinusitis, cancer, food poisoning, joint pain, and wound healing. It has also been consumed as general health tonic for improving vitality. However, research and development of this rare mushroom was hindered by its limited supply from the wild. Recent successful commercial cultivation and mass production of L. rhinocerotis TM02 has enabled numerous scientific studies to be conducted to verify claims of its bioactivity and, the efficacy and safety profile of L. rhinocerotis TM02. Scientific investigations revealed that L. rhinocerotis TM02 contains various active components such as the polysaccharides-protein complexes, β-glucan, protein, immune-modulatory proteins, all of which are biologically active in rendering significant medicinal properties such as anti-inflammatory, immuno-modulatory, anti-proliferative, antioxidative, neurite outgrowth stimulation etc. Genomic study has shown the presence of a novel fungal immuno-modulatory protein (FIP) in this mushroom. The gene sequence and three dimensional model of this novel fungal immune-modulatory protein have been recently elucidated. Pre-clinical toxicology evaluations showed that L.rhinocerotis TM02 did not induce any adverse effect on fertility, teratogenicity and genotoxicity. The no-observed adverse-effect level (NOAEL) dose of the L.rhinocerotis TM02 in a 180-day chronic toxicity study is more than 1000 mg/kg which is equivalent to 162 mg/kg human dose whilst the anticipated dose for a 60 kg adult is only ~10g. The effective dosage of L.rhinocerotis TM02 is 0.5g per day for an adult, therefore there is a wide safety margin for consumption. Based on users’ experiences and feedback, L.rhinocerotis TM02 has been shown to be effective in a broad spectrum of respiratory health and immune health conditions, maintaining the health of joints, improving vitality and stamina, and improving the quality of life of cancer patients.

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